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Indian and US researchers collaborate to develop an optogenetic tool to understand brain disorders

Researchers at Jamia Millia Islamia (JMI) in collaboration with the US National Institutes of Health (NIH) have developed an optogenetic tool to help understand brain disorders such as Alzheimer’s disease, depression and schizophrenia.

The tool could study molecular trafficking in neurons and was developed by Dr. Tanveer Ahmed, a postdoctoral trainee at NIH, before joining the varsity’s Multidisciplinary Center for Advanced Research and Studies (MCARS), JMI said in a statement. An Assistant Professor.

“Understanding the molecular details of these diseases will help in the development of targeted therapies, especially viral and mRNA-based methods that are specific to the specific target molecule in cells,” says Ahmed.

The tool can be applied to address other biological issues such as memory formation and the development of non-stimulating light-stimulating therapies for the treatment of cancer and neurodegeneration, he said.

The light-oxygen-sensing domains of light-oxygen-sensing domains have been designed by researchers to combine light-oxygen-sensing domains, abbreviated as Avena sativa (Oats) and AsLOV2, by increasing the potential of phototropic receptors known as light-oxygen-voltage-sensing domains. neuregulin3 (NRG3).

Furthermore, Alzheimer’s, schizophrenia and depression include genetic polymorphisms in NRG3, which is why it is considered a genetic predisposition to these diseases, according to the statement.

Using this innovative tool, the researchers discovered a new mechanism of protein trafficking into the hippocampal neurons in the brain, which they called “trans-synaptic retention”.

Professor Mohammed. MCARS Director Zulfiqvar said the novel’s futuristic optogenetic techniques provide unprecedented ease in understanding human diseases and finding innovative treatment solutions.

Optogenetic technology has revolutionized the field of neuroscience and shows that India is at the forefront of developing and implementing these cutting-edge technologies in collaboration with global institutes such as NIH.

A study of this has been published in the most popular peer-reviewed scientific journal – the “Journal of Cell Biology” in a statement issued by The Rockefeller University, US, JMI.

Ahmed is the lead author of the study, while Rituparna Chowdhury and Nisha Chowdhury are the other co-authors.

The team from NIH includes senior author Dr. Dr. Andres Bunano and co-authors. Detlef Woolhorst, Dr. Carlos Guardia, Dr. Irina Karavanova and Dr. Were Juan Bonifacino.


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